The Fat Barrier Principle
Apply fat — mayonnaise, butter, aioli, or olive oil — directly to the bread surface before any other ingredient. Both slices. Every time. This is not about flavor, though it adds that too. It's about physics.
Fat is hydrophobic — it repels water. Bread is made of starch, which is hygroscopic — it eagerly absorbs water. When you put a wet ingredient (tomato, cucumber, a moist protein) directly against bread with no fat barrier, the bread absorbs liquid immediately and the starch network begins to dissolve. The fat barrier creates a literal waterproofing layer between the wet filling and the bread surface, buying you 15–30 minutes of structural integrity that you don't get without it.
Applying mayonnaise or mustard only to the filling (or not at all) and wondering why the bread is soggy. The condiment needs to be on the bread, not on the turkey.
Make two identical sandwiches. On one, apply mayo to the bread. On the other, apply it to the turkey. Eat the second one 20 minutes later. The bread on the second sandwich will be demonstrably wet. This experiment is decisive.